ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: J Biol Chem. 2018; 293(6): 1865-1874MicroRNAs (miRNAs) are short RNA species, generally 19–22 nucleotides in length, which mediate post-transcriptional down-regulation of protein expression (28). Given that miRNAs exert such pervasive effects on biological processes, it is not surprising that they have an effect on GC action at several points. Their touch...

Brief summary: This review article draws on existing studies of type 1 diabetes (T1D) in sub-Saharan Africa, examining differences in phenotype, genetic susceptibility and rates of autoimmunity within this population. Lack of large prospective studies with well-standardized methodologies are noted in this population, making more definitive studies necessary.This article reviews studies reporting the clinical features of patients with T1D in sub-Saharan A...

jcmbanya@yahoo.co.uk Pediatr Diabetes 2022; 23: 33–37. doi: 10.1111/pedi.13294Brief Summary: Despite provision of free insulin by the Changing Diabetes in Children (CDiC) program, mortality remains high in children and adolescents with type 1 diabetes (T1D) in Cameroon, in particular in rural settings and in families with no formal education.<p cl...

To read the full abstract: Cancer. 2018;124:2220-2227The Brief Coping Orientation to Problem Experience (brief COPE) questionnaire was designed to explore the coping strategies used by individuals in response to stress. It has been used to research various populations with chronic health conditions (1). ‘Betweenness centrality’ is a measure of centrality in a graph based on shortest path...

To read the full abstract: Lancet Diabetes Endocrinol. 2018;6:122-129T1DM formerly called juvenile or insulin dependent diabetes has so far been considered to be a disease of children adolescents and young adults according to traditional teaching. LADA or late autoimmune diabetes of the adult is known since several decades, however the older the patient with new onset diabetes the more li...

To read the full abstract: Proc Natl Acad Sci U S A 2018;115:E832-E840Women live longer than men in nearly all modern populations. They can expect to live longer than men almost anywhere in the world. This pervasive inequality has intrigued researchers for decades, and many conclude that the gap has biological foundations, which are modulated by social and environmental conditions.<p class=...

To read the full abstract: Cell Reports. 2018 Dec 4;25(10):2643–2652.e4.More on the gut and the reward response: Ghrelin has been reported to encourage eating through dopamine that is important for the reward response. Here, the authors injected 38 subjects with ghrelin, while exposing them to various odors, both food and non-food based. They were also shown r...

To read the full abstract: J Clin Endocrinol Metab. 2019 Dec 1;104(12):5737–5750. doi: 10.1210/jc.2019-00631. PMID: 31504653.This paper describes two genes and three syndromes that clinicians would probably like to know when treating patients with a syndromic form of panhypopituitarism. Heterozygous mutation in a maternally imprinted gene, MAGEL2, was described in four patients...

To read the full abstract: Diabetes Care. 2018;41:303-310One of the major short term complications of T1DM is the imminent risk of hypoglycemia during insulin treatment. In addition and importantly, long term complications of diabetes include those induced by frequent hypoglycemia, namely neurologic and developmental impairment upon frequent hypoglycemic episodes at a young age. In addition, it is de...

To read the full abstract: J Public Health (Oxf) 2017:1-9Our efforts to control overweight and obesity in children are severely hampered because most of their parents (and indeed most of their health professionals!) cannot visually recognise an obese child, let alone one who is overweight. This is particularly difficult at around the ages 4-6 years old because this coincides with the BMI n...